Polyurethanes yog siv dav hauv kev siv tshuaj biomedical xws li daim tawv nqaij, lub txaj pw hauv tsev kho mob, cov raj lim dej, cov khoom siv pacemaker, catheters, thiab cov txheej txheem phais.Cov biocompatibility, txhua yam khoom, thiab tus nqi qis yog qhov tseem ceeb rau kev ua tiav ntawm polyurethanes hauv kev kho mob.

Txoj kev loj hlob ntawm kev cog qoob loo feem ntau yuav tsum muaj cov ntsiab lus siab ntawm biobased Cheebtsam, vim tias lub cev tsis lees txais lawv tsawg dua.Nyob rau hauv cov ntaub ntawv ntawm polyurethanes, lub biocomponent tuaj yeem sib txawv ntawm 30 mus rau 70%, uas tsim kom muaj kev dav dav rau cov ntawv thov hauv thaj chaw xws li (2).Cov biobased polyurethanes tau nce lawv txoj kev lag luam thiab xav tias yuav ncav cuag li $ 42 lab los ntawm 2022, uas yog qhov feem pua ​​​​ntawm cov lag luam polyurethane tag nrho (tsawg dua 0.1%).Txawm li cas los xij, nws yog thaj chaw muaj kev cia siab, thiab kev tshawb fawb hnyav tau txuas ntxiv txog kev siv cov khoom siv biobased ntau hauv polyurethanes.Kev txhim kho yog xav tau nyob rau hauv cov khoom ntawm biobased polyurethanes kom phim cov kev xav tau uas twb muaj lawm, txhawm rau txhawm rau nce peev.

Biobased crystalline polyurethane tau tsim los ntawm cov tshuaj tiv thaiv ntawm PCL, HMDI, thiab dej uas ua lub luag haujlwm ntawm cov saw txuas ntxiv (33).Kev kuaj degradation tau ua los kawm txog kev ruaj ntseg ntawm biopolyurethane hauv simulated lub cev kua, xws li phosphate-buffered saline kua.Cov kev hloov

nyob rau hauv thermal, mechanical, thiab lub cev muaj zog tau txheeb xyuas thiab muab piv rau qhov sib npaug

polyurethane tau los ntawm kev siv ethylene glycol ua cov saw txuas ntxiv es tsis txhob dej.Cov txiaj ntsig tau pom tias cov polyurethane tau txais kev siv dej los ua cov saw txuas ntxiv nthuav tawm cov khoom zoo dua nyob rau lub sijhawm piv nrog nws qhov sib npaug petrochemical.Qhov no tsis tsuas yog txo qis heev

tus nqi ntawm cov txheej txheem, tab sis nws kuj muab txoj hauv kev yooj yim kom tau txais cov khoom siv kho mob ntxiv uas tsim nyog rau kev sib koom ua ke endoprostheses (33).Qhov no tau ua raws li lwm txoj hauv kev raws li lub tswv yim no, uas tau tsim cov biopolyurethane urea los ntawm kev siv rapeseed roj-raws li polyol, PCL, HMDI, thiab dej ua cov saw txuas (6).Txhawm rau ua kom thaj chaw saum npoo av, sodium chlorine tau siv los txhim kho qhov porosity ntawm cov polymers npaj.Lub synthesized polymer yog siv los ua ib qho scaffold vim nws cov qauv ntxeem tau los txhawb kev loj hlob ntawm tes ntawm cov pob txha.Nrog cov txiaj ntsig zoo sib xws

rau qhov piv txwv yav dhau los, cov polyurethane uas tau raug simulated lub cev kua qhia kev ruaj ntseg siab, muab kev xaiv siv tau rau kev siv scaffold.Polyurethane ionomers yog lwm chav kawm nthuav dav ntawm cov polymers siv rau kev siv biomedical, vim lawv cov biocompatibility thiab kev sib raug zoo nrog lub cev ib puag ncig.Polyurethane ionomers tuaj yeem siv los ua cov khoom siv raj rau pacemakers thiab hemodialysis (34, 35).

Kev txhim kho ntawm kev xa tshuaj zoo yog qhov tseem ceeb hauv cheeb tsam tshawb fawb uas tam sim no tsom mus rau kev nrhiav txoj hauv kev los daws cov mob qog noj ntshav.Ib qho amphiphilic nanoparticle ntawm polyurethane raws li L-lysine tau npaj rau daim ntawv thov xa tshuaj (36).Qhov no nanocarrier

tau txais txiaj ntsig zoo nrog doxorubicin, uas yog ib qho tshuaj kho tau zoo rau cov qog nqaij hlav cancer (Daim duab 16).Cov ntu hydrophobic ntawm polyurethane cuam tshuam nrog cov tshuaj, thiab ntu hydrophilic cuam tshuam nrog cov hlwb.Qhov no system tsim ib tug core-plhaub qauv los ntawm ib tug self-assembly

mechanism thiab muaj peev xwm xa cov tshuaj zoo ntawm ob txoj hauv kev.Ua ntej, cov lus teb thermal ntawm nanoparticle ua raws li qhov ua rau tso cov tshuaj ntawm cov qog nqaij hlav cancer ntawm qhov kub (~ 41-43 ° C), uas yog cov lus teb ntxiv.Qhov thib ob, ntu aliphatic ntawm polyurethane raug kev txom nyem

enzymatic biodegradation los ntawm kev ua ntawm lysosomes, tso cai rau doxorubicin tso rau hauv cov qog nqaij hlav cancer;Qhov no yog ib qho lus teb intracellular.Ntau tshaj 90% ntawm cov qog nqaij hlav cancer mis raug tua, thaum tsis muaj cytotoxicity tau tswj xyuas cov hlwb noj qab haus huv.

Daim duab 16. Zuag qhia tag nrho cov txheej txheem rau kev xa tshuaj raws li amphiphilic polyurethane nanoparticle

tsom rau cov qog nqaij hlav cancer. Luam tawm nrog kev tso cai los ntawm kev siv(36).Copyright 2019 Asmeskas Tshuaj

Lub koom haum.

Kev Tshaj Tawm: Cov kab lus tau hais los ntawmTaw qhia rau Polyurethane ChemistryFelipe M. de Souza, 1 Pawan K. Kahol, 2 thiab Ram K.Gupta *,1 .Tsuas yog rau kev sib txuas lus thiab kev kawm, tsis txhob ua lwm yam kev lag luam lub hom phiaj, tsis sawv cev rau lub tuam txhab kev pom thiab kev xav, yog tias koj xav tau rov luam dua, thov hu rau tus thawj sau, yog tias muaj kev ua txhaum cai, thov hu rau peb tam sim ntawd kom tshem tawm cov txheej txheem.